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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50514307
Substrate
n/a
Meas. Tech.
ChEMBL_1856270 (CHEMBL4356999)
EC50
324±n/a nM
Citation
 Sinha, N; Karche, NP; Verma, MK; Walunj, SS; Nigade, PB; Jana, G; Kurhade, SP; Hajare, AK; Tilekar, AR; Jadhav, GR; Thube, BR; Shaikh, JS; Balgude, S; Singh, LB; Mahimane, V; Adurkar, SK; Hatnapure, G; Raje, F; Bhosale, Y; Bhanage, D; Sachchidanand, S; Dixit, R; Gupta, R; Bokare, AM; Dandekar, M; Bharne, A; Chatterjee, M; Desai, S; Koul, S; Modi, D; Mehta, M; Patil, V; Singh, M; Gundu, J; Goel, RN; Shah, C; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of ?7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization. J Med Chem 63:944-960 (2020) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50514307
Synonyms:
CHEMBL4457158
Type:
Small organic molecule
Emp. Form.:
C20H18ClNO3S2
Mol. Mass.:
419.945
SMILES:
CCC(=O)c1sc(c(C)c1-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: