Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 1
Ligand
BDBM50514308
Substrate
n/a
Meas. Tech.
ChEMBL_1856378 (CHEMBL4357107)
IC50
2.0±n/a nM
Citation
 Wang, WW; Gallo, L; Jadhav, A; Hawkins, R; Parker, CG The Druggability of Solute Carriers. J Med Chem 63:3834-3867 (2020) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:
GLUT-1 | GLUT1 | GTR1_HUMAN | Glucose Transporter 1 (hGLUT1) | Glucose transporter | Glucose transporter type 1, erythrocyte/brain | HepG2 glucose transporter | SLC2A1
Type:
Protein
Mol. Mass.:
54091.71
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
492
Sequence:
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
  
Inhibitor
Name:
BDBM50514308
Synonyms:
CHEMBL4448899
Type:
Small organic molecule
Emp. Form.:
C24H16F4N6O2
Mol. Mass.:
496.4165
SMILES:
Cc1c(NC(=O)c2cc(nc3cc(F)ccc23)C(N)=O)c(nn1Cc1ccc(cc1)C#N)C(F)(F)F
Structure:
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