Reaction Details Report a problem with these data
Target
Calcium-activated potassium channel subunit beta-4
Ligand
BDBM50514444
Substrate
n/a
Meas. Tech.
ChEMBL_1856724 (CHEMBL4357453)
IC50
602±n/a nM
Citation
 Liu, X; Tao, J; Zhang, S; Lan, W; Wang, C; Ji, Y; Cao, C Selective Blockade of Neuronal BK (? + ?4) Channels Preventing Epileptic Seizure. J Med Chem 63:216-230 (2020) [PubMed]  Article 
Target
Name:
Calcium-activated potassium channel subunit beta-4
Synonyms:
BK channel subunit beta-4 | BKbeta4 | Calcium-activated potassium channel subunit beta-4 | Calcium-activated potassium channel, subfamily M subunit beta-4 | Charybdotoxin receptor subunit beta-4 | Hbeta4 | K(VCA)beta-4 | KCMB4_HUMAN | KCNMB4 | Maxi K channel subunit beta-4 | Slo-beta-4
Type:
PROTEIN
Mol. Mass.:
23949.41
Organism:
Homo sapiens
Description:
ChEMBL_119330
Residue:
210
Sequence:
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
  
Inhibitor
Name:
BDBM50514444
Synonyms:
CHEMBL4516172
Type:
Small organic molecule
Emp. Form.:
C175H269N51O55S6
Mol. Mass.:
4159.707
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](N[C@@H](CCCNC(N)=N)C(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC1=O)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N3)N[C@@H](CCC(N)=O)C(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)C(C)C)[C@@H](C)O |r|
Structure:
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