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Target
Bromodomain-containing protein 7
Ligand
BDBM50183448
Substrate
n/a
Meas. Tech.
ChEMBL_1858080 (CHEMBL4358809)
Kd
121±n/a nM
Citation
 Karim, RM; Chan, A; Zhu, JY; Schönbrunn, E Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J Med Chem 63:3227-3237 (2020) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 7
Synonyms:
75 kDa bromodomain protein | BP75 | BRD7 | BRD7_HUMAN | CELTIX1 | Protein CELTIX-1
Type:
PROTEIN
Mol. Mass.:
74135.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107970
Residue:
651
Sequence:
MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS
  
Inhibitor
Name:
BDBM50183448
Synonyms:
CHEMBL3823478 | US11773085, Compound B2
Type:
Small organic molecule
Emp. Form.:
C20H23N3O3
Mol. Mass.:
353.4149
SMILES:
COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2cnccc12
Structure:
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