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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50069875
Substrate
n/a
Meas. Tech.
ChEBML_28186
IC50
230±n/a nM
Citation
 Lee, HT; Roark, WH; Picard, JA; Sliskovic, DR; Roth, BD; Stanfield, RL; Hamelehle, KL; Bousley, RF; Krause, BR Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett 8:289-94 (1999) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50069875
Synonyms:
(2,6-Diisopropyl-phenylsulfamoyl)-acetic acid tetradecyl ester | CHEMBL100573
Type:
Small organic molecule
Emp. Form.:
C28H49NO4S
Mol. Mass.:
495.758
SMILES:
CCCCCCCCCCCCCCOC(=O)CS(=O)(=O)Nc1c(cccc1C(C)C)C(C)C
Structure:
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