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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50069884
Substrate
n/a
Meas. Tech.
ChEBML_28186
IC50
>1000±n/a nM
Citation
 Lee, HT; Roark, WH; Picard, JA; Sliskovic, DR; Roth, BD; Stanfield, RL; Hamelehle, KL; Bousley, RF; Krause, BR Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett 8:289-94 (1999) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50069884
Synonyms:
(2,6-Diisopropyl-phenylsulfamoyl)-acetic acid 2,4,6-trimethoxy-phenyl ester | CHEMBL418976
Type:
Small organic molecule
Emp. Form.:
C23H31NO7S
Mol. Mass.:
465.56
SMILES:
COc1cc(OC)c(OC(=O)CS(=O)(=O)Nc2c(cccc2C(C)C)C(C)C)c(OC)c1
Structure:
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