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Target
Deoxyhypusine synthase
Ligand
BDBM50514710
Substrate
n/a
Meas. Tech.
ChEMBL_1858218 (CHEMBL4358947)
IC50
6900±n/a nM
Citation
 Tanaka, Y; Kurasawa, O; Yokota, A; Klein, MG; Ono, K; Saito, B; Matsumoto, S; Okaniwa, M; Ambrus-Aikelin, G; Morishita, D; Kitazawa, S; Uchiyama, N; Ogawa, K; Kimura, H; Imamura, S Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase. J Med Chem 63:3215-3226 (2020) [PubMed]  Article 
Target
Name:
Deoxyhypusine synthase
Synonyms:
2.5.1.46 | DHPS | DHS | DHYS_HUMAN | DS | Deoxyhypusine synthase
Type:
PROTEIN
Mol. Mass.:
40962.06
Organism:
Homo sapiens
Description:
ChEMBL_18047
Residue:
369
Sequence:
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFMHEKNED
  
Inhibitor
Name:
BDBM50514710
Synonyms:
CHEMBL4555677
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2OS
Mol. Mass.:
371.251
SMILES:
Brc1ccc2cc(sc2c1)C(=O)Nc1cccc2[nH]ccc12
Structure:
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