Reaction Details
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Alpha-2A adrenergic receptor
Ligand
BDBM50086502
Substrate
n/a
Meas. Tech.
ChEMBL_1858221 (CHEMBL4358950)
Ki
229±n/a nM
Citation
Abás, S; Rodríguez-Arévalo, S; Bagán, A; Grińán-Ferré, C; Vasilopoulou, F; Brocos-Mosquera, I; Muguruza, C; Pérez, B; Molins, E; Luque, FJ; Pérez-Lozano, P; de Jonghe, S; Daelemans, D; Naesens, L; Brea, J; Loza, MI; Hernández-Hernández, E; García-Sevilla, JA; García-Fuster, MJ; Radan, M; Djikic, T; Nikolic, K; Pallŕs, M; Callado, LF; Escolano, C Bicyclic ?-Iminophosphonates as High Affinity Imidazoline I J Med Chem 63:3610-3633 (2020) [PubMed] Article More Info.:
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
465
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Inhibitor
Name:
BDBM50086502
Synonyms:
2-BFi | 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole | CHEMBL404505
Type:
Small organic molecule
Emp. Form.:
C11H10N2O
Mol. Mass.:
186.2099
SMILES:
C1CN=C(N1)c1cc2ccccc2o1 |c:2|
Structure:
