Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50070212
Substrate
n/a
Meas. Tech.
ChEBML_86750
Ki
3.7±n/a nM
Citation
 Ali, SM; Tedford, CE; Gregory, R; Yates, SL; Phillips, JG New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett 8:1133-8 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50070212
Synonyms:
4-(7-Methyl-oct-3-ynyl)-1H-imidazole | CHEMBL14497
Type:
Small organic molecule
Emp. Form.:
C12H18N2
Mol. Mass.:
190.2847
SMILES:
CC(C)CCC#CCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: