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Target
Protein Mdm4
Ligand
BDBM50515635
Substrate
n/a
Meas. Tech.
ChEMBL_1861961 (CHEMBL4362817)
Ki
12600±n/a nM
Citation
 Neochoritis, CG; Atmaj, J; Twarda-Clapa, A; Surmiak, E; Skalniak, L; Köhler, LM; Muszak, D; Kurpiewska, K; Kalinowska-T?u?cik, J; Beck, B; Holak, TA; Dömling, A Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50515635
Synonyms:
CHEMBL4451093
Type:
Small organic molecule
Emp. Form.:
C30H29ClFN3O5
Mol. Mass.:
566.02
SMILES:
CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(F)cc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O
Structure:
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