Reaction Details
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Protein Mdm4
Ligand
BDBM50515627
Substrate
n/a
Meas. Tech.
ChEMBL_1861961 (CHEMBL4362817)
Ki
1680±n/a nM
Citation
Neochoritis, CG; Atmaj, J; Twarda-Clapa, A; Surmiak, E; Skalniak, L; Köhler, LM; Muszak, D; Kurpiewska, K; Kalinowska-T?u?cik, J; Beck, B; Holak, TA; Dömling, A Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction. Eur J Med Chem 182:0 (2019) [PubMed] Article More Info.:
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Inhibitor
Name:
BDBM50515627
Synonyms:
CHEMBL4553260
Type:
Small organic molecule
Emp. Form.:
C36H35BrClN3O5
Mol. Mass.:
705.037
SMILES:
OC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(Cc1ccc(OCc2ccccc2Br)cc1)C=O)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:35:36:38:42.40.41,THB:40:39:36:42.41.43,40:41:36:38.39.45,43:41:38:36.45.44,43:44:38:42.40.41,(62.85,-14.7,;62.09,-13.36,;62.86,-12.03,;60.55,-13.36,;59.64,-14.6,;58.17,-14.12,;56.84,-14.9,;55.5,-14.12,;54.17,-14.89,;55.51,-12.58,;56.84,-11.81,;58.18,-12.58,;59.64,-12.11,;60.12,-10.64,;59.1,-9.5,;57.59,-9.81,;56.56,-8.66,;57.05,-7.2,;56.02,-6.06,;54.51,-6.37,;53.49,-5.23,;51.98,-5.55,;50.95,-4.4,;49.45,-4.72,;48.42,-3.58,;48.89,-2.11,;50.4,-1.79,;51.43,-2.94,;52.94,-2.62,;54.04,-7.85,;55.07,-8.99,;59.58,-8.03,;58.55,-6.88,;61.63,-10.33,;62.89,-11.2,;62.11,-8.86,;63.62,-8.55,;64.71,-9.56,;64.82,-11.31,;65.54,-9.92,;66.91,-9.28,;66.67,-7.66,;65.97,-8.92,;65.56,-6.61,;64.18,-7.24,;64.37,-8.84,)|
Structure:
