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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50515702
Substrate
n/a
Meas. Tech.
ChEMBL_1862183 (CHEMBL4363039)
IC50
42900±n/a nM
Citation
 Esposito, F; Ambrosio, FA; Maleddu, R; Costa, G; Rocca, R; Maccioni, E; Catalano, R; Romeo, I; Eleftheriou, P; Karia, DC; Tsirides, P; Godvani, N; Pandya, H; Corona, A; Alcaro, S; Artese, A; Geronikaki, A; Tramontano, E Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50515702
Synonyms:
CHEMBL4467593
Type:
Small organic molecule
Emp. Form.:
C29H18N2O5
Mol. Mass.:
474.4636
SMILES:
Cc1ccc2oc(=O)c3cc(C4=Nc5ccc(cc5N=CC4)C(=O)c4ccccc4)c(=O)oc3c2c1 |c:20,t:11|
Structure:
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