Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50515697
Substrate
n/a
Meas. Tech.
ChEMBL_1862185 (CHEMBL4363041)
IC50
41500±n/a nM
Citation
 Esposito, F; Ambrosio, FA; Maleddu, R; Costa, G; Rocca, R; Maccioni, E; Catalano, R; Romeo, I; Eleftheriou, P; Karia, DC; Tsirides, P; Godvani, N; Pandya, H; Corona, A; Alcaro, S; Artese, A; Geronikaki, A; Tramontano, E Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50515697
Synonyms:
CHEMBL4440430
Type:
Small organic molecule
Emp. Form.:
C13H8O5
Mol. Mass.:
244.1996
SMILES:
Cc1ccc2c(c1)oc(=O)c1c(O)cc(=O)oc21
Structure:
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