Reaction Details Report a problem with these data
Target
Cytochrome c oxidase subunit 2
Ligand
BDBM50515745
Substrate
n/a
Meas. Tech.
ChEMBL_1862266 (CHEMBL4363122)
IC50
915±n/a nM
Citation
 Kumar, R; Saha, N; Purohit, P; Garg, SK; Seth, K; Meena, VS; Dubey, S; Dave, K; Goyal, R; Sharma, SS; Banerjee, UC; Chakraborti, AK Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Cytochrome c oxidase subunit 2
Synonyms:
COII | COX2 | COX2_HUMAN | COXII | MT-CO2 | MTCO2
Type:
PROTEIN
Mol. Mass.:
25555.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_530099
Residue:
227
Sequence:
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
  
Inhibitor
Name:
BDBM50515745
Synonyms:
CHEMBL4474644
Type:
Small organic molecule
Emp. Form.:
C17H20ClNO3
Mol. Mass.:
321.799
SMILES:
CC(C)(C)OC(=O)N(C1=CC(=O)CCC1)c1ccc(Cl)cc1 |t:8|
Structure:
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