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Target
Coagulation factor X
Ligand
BDBM50071051
Substrate
n/a
Meas. Tech.
ChEBML_48992
Ki
560±n/a nM
Citation
 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors. Bioorg Med Chem Lett 8:1877-82 (1999) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50071051
Synonyms:
3-(3',5'-Difluoro-4,4'-dimethyl-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-yloxy)-benzamidine | CHEMBL417750
Type:
Small organic molecule
Emp. Form.:
C25H26F2N4O
Mol. Mass.:
436.4969
SMILES:
Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCC(C)(CC2)c2ccccc2)c1F
Structure:
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