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Target
Coagulation factor X
Ligand
BDBM50071053
Substrate
n/a
Meas. Tech.
ChEBML_48992
Ki
>5000±n/a nM
Citation
 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors. Bioorg Med Chem Lett 8:1877-82 (1999) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50071053
Synonyms:
3-{3,5-Difluoro-4-methyl-6-[4-(2-morpholin-4-yl-2-oxo-ethyl)-piperazin-1-yl]-pyridin-2-yloxy}-benzamidine | CHEMBL442554
Type:
Small organic molecule
Emp. Form.:
C23H28F2N6O3
Mol. Mass.:
474.5036
SMILES:
Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCN(CC(=O)N3CCOCC3)CC2)c1F
Structure:
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