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Target
Cholesteryl ester transfer protein
Ligand
BDBM50516399
Substrate
n/a
Meas. Tech.
ChEMBL_1865110 (CHEMBL4366085)
IC50
53.0±n/a nM
Citation
 Finlay, HJ; Jiang, J; Rampulla, R; Salvati, ME; Qiao, JX; Wang, TC; Lawrence, RM; Harikrishnan, LS; Kamau, MG; Taylor, DS; Chen, AYA; Yin, X; Huang, CS; Chang, M; Chen, XQ; Sleph, PG; Xu, C; Li, J; Levesque, P; Adam, LP; Wexler, RR Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor. ACS Med Chem Lett 10:911-916 (2019) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50516399
Synonyms:
CHEMBL4448253
Type:
Small organic molecule
Emp. Form.:
C26H19ClF11N3O3
Mol. Mass.:
665.883
SMILES:
NC(C(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)C(O)(C(F)(F)F)C(F)(F)F |r|
Structure:
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