Reaction Details Report a problem with these data
Target
Calpain-1 catalytic subunit
Ligand
BDBM50071828
Substrate
n/a
Meas. Tech.
ChEBML_43648
IC50
13±n/a nM
Citation
Tripathy, R; Gu, ZQ; Dunn, D; Senadhi, SE; Ator, MA; Chatterjee, S P2-proline-derived inhibitors of calpain I. Bioorg Med Chem Lett 8:2647-52 (1999) [PubMed] Article
More Info.:
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:
Protein
Mol. Mass.:
81880.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
Inhibitor
Name:
BDBM50071828
Synonyms:
Benzenesulfonic acid (3R,5S)-1-benzenesulfonyl-5-((S)-1-benzyl-2-oxo-ethylcarbamoyl)-pyrrolidin-3-yl ester | CHEMBL87146
Type:
Small organic molecule
Emp. Form.:
C26H26N2O7S2
Mol. Mass.:
542.624
SMILES:
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](CN1S(=O)(=O)c1ccccc1)OS(=O)(=O)c1ccccc1