Reaction Details
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GTPase KRas
Ligand
BDBM50517187
Substrate
n/a
Meas. Tech.
ChEMBL_1867403 (CHEMBL4368378)
Kd
20000±n/a nM
Citation
Shin, Y; Jeong, JW; Wurz, RP; Achanta, P; Arvedson, T; Bartberger, MD; Campuzano, IDG; Fucini, R; Hansen, SK; Ingersoll, J; Iwig, JS; Lipford, JR; Ma, V; Kopecky, DJ; McCarter, J; San Miguel, T; Mohr, C; Sabet, S; Saiki, AY; Sawayama, A; Sethofer, S; Tegley, CM; Volak, LP; Yang, K; Lanman, BA; Erlanson, DA; Cee, VJ Discovery of ACS Med Chem Lett 10:1302-1308 (2019) [PubMed] Article More Info.:
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Inhibitor
Name:
BDBM50517187
Synonyms:
CHEMBL4464335 | US11053226, Example 1-7
Type:
Small organic molecule
Emp. Form.:
C31H33ClN4O4
Mol. Mass.:
561.071
SMILES:
COc1cccc2CN(CCc12)C(=O)c1c(C2CC2)n(CC(=O)NC2CN(C2)C(=O)C=C)c2c(C)cc(Cl)cc12
Structure:
