Target
Inositol polyphosphate multikinase
Ligand
BDBM50187658
Substrate
n/a
Meas. Tech.
ChEMBL_1868988 (CHEMBL4370054)
IC50
>30000±n/a nM
Citation
 Gu, CStashko, MAPuhl-Rubio, ACChakraborty, MChakraborty, AFrye, SVPearce, KHWang, XShears, SBWang, H Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J Med Chem 62:1443-1454 (2019) [PubMed]  Article 
Target
Name:
Inositol polyphosphate multikinase
Synonyms:
2.7.1.140 | 2.7.1.151 | 2.7.1.153 | IMPK | IPMK | IPMK_HUMAN | Inositol 1,3,4,6-tetrakisphosphate 5-kinase | Inositol polyphosphate multikinase
Type:
PROTEIN
Mol. Mass.:
47229.24
Organism:
Homo sapiens
Description:
ChEMBL_119151
Residue:
416
Sequence:
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
  
Inhibitor
Name:
BDBM50187658
Synonyms:
4',5-dihydroxy-7-methoxy flavone | 4',5-dihydroxy-7-methoxyflavone | 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one | 7-O-methylapigenin | CHEMBL210635 | Gonkwanin | genkwanin
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: