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Target
Lactoylglutathione lyase
Ligand
BDBM50402202
Substrate
n/a
Meas. Tech.
ChEMBL_1869139 (CHEMBL4370205)
Ki
11±n/a nM
Citation
 Perez, C; Barkley-Levenson, AM; Dick, BL; Glatt, PF; Martinez, Y; Siegel, D; Momper, JD; Palmer, AA; Cohen, SM Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem 62:1609-1625 (2019) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50402202
Synonyms:
CHEMBL2203964
Type:
Small organic molecule
Emp. Form.:
C22H21N3O3
Mol. Mass.:
375.4204
SMILES:
COCCCn1ccc2cc(cnc12)-c1cc(cc(=O)n1O)-c1ccccc1
Structure:
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