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Target
Proteasome subunit beta type-10
Ligand
BDBM50517625
Substrate
n/a
Meas. Tech.
ChEMBL_1869378 (CHEMBL4370444)
IC50
45±n/a nM
Citation
 Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, Y; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits. J Med Chem 62:1626-1642 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50517625
Synonyms:
CHEMBL4515041
Type:
Small organic molecule
Emp. Form.:
C38H57N5O5S2
Mol. Mass.:
728.02
SMILES:
CC(C)C[C@H](NC(=O)c1cnc(C)s1)C(=O)N[C@@H](CC1CCC(CC1)C1CCCCC1)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r,wU:17.18,wD:34.37,4.3,(15.13,-25.2,;13.81,-25.98,;13.82,-27.51,;12.48,-25.22,;12.48,-23.68,;11.14,-22.91,;9.81,-23.68,;9.81,-25.22,;8.48,-22.91,;7.08,-23.52,;6.05,-22.38,;6.82,-21.05,;6.2,-19.65,;8.32,-21.38,;13.81,-22.91,;13.81,-21.37,;15.14,-23.68,;16.48,-22.91,;16.48,-21.37,;17.81,-20.6,;19.14,-21.38,;20.46,-20.62,;20.48,-19.07,;19.14,-18.3,;17.8,-19.06,;21.81,-18.31,;23.14,-19.09,;24.47,-18.33,;24.48,-16.79,;23.15,-16.01,;21.81,-16.77,;17.81,-23.68,;17.81,-25.22,;19.14,-22.91,;20.48,-23.68,;20.48,-25.22,;21.81,-25.99,;21.8,-27.53,;23.14,-28.3,;24.47,-27.53,;25.81,-28.3,;27.14,-27.52,;24.47,-25.98,;23.13,-25.22,;21.81,-22.91,;23.15,-23.68,;24.48,-22.9,;25.81,-23.68,;23.7,-21.56,;25.25,-21.56,)|
Structure:
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