Reaction Details Report a problem with these data
Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50350248
Substrate
n/a
Meas. Tech.
ChEMBL_1869799 (CHEMBL4370865)
Ki
5500±n/a nM
Citation
 Yang, L; Chen, Y; He, J; Njoya, EM; Chen, J; Liu, S; Xie, C; Huang, W; Wang, F; Wang, Z; Li, Y; Qian, S 4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors. Bioorg Med Chem 27:1087-1098 (2019) [PubMed]  Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM50350248
Synonyms:
CHEMBL1812545
Type:
Small organic molecule
Emp. Form.:
C11H8FN5
Mol. Mass.:
229.2131
SMILES:
Fc1ccc2c(C=Cc3nnn[nH]3)c[nH]c2c1 |w:6.5|
Structure:
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