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Target
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM50518060
Substrate
n/a
Meas. Tech.
ChEMBL_1870515 (CHEMBL4371682)
IC50
2.4±n/a nM
Citation
 Devasthale, P; Cheng, D Monoacylglycerol Acyltransferase 2 (MGAT2) Inhibitors for the Treatment of Metabolic Diseases and Nonalcoholic Steatohepatitis (NASH). J Med Chem 61:9879-9888 (2018) [PubMed]  Article 
Target
Name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2_MOUSE | Mannoside acetylglucosaminyltransferase 2 | Mgat2 | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Type:
PROTEIN
Mol. Mass.:
51045.37
Organism:
Mus musculus
Description:
ChEMBL_107583
Residue:
442
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKSDALGPPLLDAEPVRGAGHLAVSVGIRRVSNESAAPLVPAVPRPEVDNLTLRYRSLVYQLNFDQMLRNVGNDGTWSPGELVLVVQVHNRPEYLRLLIDSLRKAQGIQEVLVIFSHDFWSAEINSLISRVDFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLKKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLQDYTGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTLACLPKIWKVLVPQAPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYLFPETLVIGEKFPMAAISPPRKNGGWGDIRDHELCKSYRRLQ
  
Inhibitor
Name:
BDBM50518060
Synonyms:
CHEMBL4455357
Type:
Small organic molecule
Emp. Form.:
C27H21ClF5N7O3S
Mol. Mass.:
654.011
SMILES:
Cn1nc(cc1-c1cnc(nc1)N1CCc2cc(cc(N3CCCC3=O)c12)S(=O)(=O)Nc1c(F)cc(Cl)cc1F)C(F)(F)F
Structure:
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