Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50518087
Substrate
n/a
Meas. Tech.
ChEMBL_1870528 (CHEMBL4371695)
Ki
18±n/a nM
Citation
 Ortiz Zacarķas, NV; van Veldhoven, JPD; Portner, L; van Spronsen, E; Ullo, S; Veenhuizen, M; van der Velden, WJC; Zweemer, AJM; Kreekel, RM; Oenema, K; Lenselink, EB; Heitman, LH; IJzerman, AP Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2. J Med Chem 61:9146-9161 (2018) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50518087
Synonyms:
CHEMBL4471583
Type:
Small organic molecule
Emp. Form.:
C21H25NO3
Mol. Mass.:
339.4281
SMILES:
Cc1ccc(cc1)N1C(C2CCCCC2)C(C(=O)C2CC2)=C(O)C1=O |t:23|
Structure:
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