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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM50518211
Substrate
n/a
Meas. Tech.
ChEMBL_1870735 (CHEMBL4371902)
IC50
2754±n/a nM
Citation
 Hauke, TJ; Höfner, G; Wanner, KT Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4. Bioorg Med Chem 27:144-152 (2019) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
GABA transporter 3 | GABT3 | GAT-3 | GAT3 | S6A11_HUMAN | SLC6A11 | Solute carrier family 6 member 11
Type:
PROTEIN
Mol. Mass.:
70607.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454198
Residue:
632
Sequence:
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
  
Inhibitor
Name:
BDBM50518211
Synonyms:
CHEMBL4447559
Type:
Small organic molecule
Emp. Form.:
C19H19ClFN3O2
Mol. Mass.:
375.824
SMILES:
OC(=O)[C@H]1CNC[C@H](C1)N\N=C\c1cc(F)ccc1-c1ccc(Cl)cc1 |r|
Structure:
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