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Target
E3 SUMO-protein ligase CBX4
Ligand
BDBM50519512
Substrate
n/a
Meas. Tech.
ChEMBL_1875893 (CHEMBL4377287)
Kd
94±n/a nM
Citation
 Xiong, Y; Greschik, H; Johansson, C; Seifert, L; Bacher, J; Park, KS; Babault, N; Martini, M; Fagan, V; Li, F; Chau, I; Christott, T; Dilworth, D; Barsyte-Lovejoy, D; Vedadi, M; Arrowsmith, CH; Brennan, P; Fedorov, O; Jung, M; Farnie, G; Liu, J; Oppermann, U; Schüle, R; Jin, J Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J Med Chem 62:8996-9007 (2019) [PubMed]  Article 
Target
Name:
E3 SUMO-protein ligase CBX4
Synonyms:
6.3.2.- | CBX4 | CBX4_HUMAN | Chromobox protein homolog 4 | Pc2 | Polycomb 2 homolog | hPc2
Type:
PROTEIN
Mol. Mass.:
61401.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108273
Residue:
560
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
  
Inhibitor
Name:
BDBM50519512
Synonyms:
CHEMBL4449240
Type:
Small organic molecule
Emp. Form.:
C37H62N6O8
Mol. Mass.:
718.9236
SMILES:
CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC |r|
Structure:
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