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Target
Dual serine/threonine and tyrosine protein kinase
Ligand
BDBM50428286
Substrate
n/a
Meas. Tech.
ChEMBL_1877356 (CHEMBL4378750)
IC50
29350±n/a nM
Citation
 Zhuang, C; Chen, F Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. J Med Chem 63:1490-1510 (2020) [PubMed]  Article 
Target
Name:
Dual serine/threonine and tyrosine protein kinase
Synonyms:
DSTYK | DUSTY_HUMAN | Dusty PK | Dusty protein kinase | KIAA0472 | RIP-homologous kinase | RIP5 | RIPK5 | Receptor-interacting serine/threonine-protein kinase 5 | SGK496 | Sugen kinase 496
Type:
PROTEIN
Mol. Mass.:
105208.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774238
Residue:
929
Sequence:
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST
  
Inhibitor
Name:
BDBM50428286
Synonyms:
DABRAFENIB | GSK2118436A
Type:
Small organic molecule
Emp. Form.:
C23H20F3N5O2S2
Mol. Mass.:
519.562
SMILES:
CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Structure:
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