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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50519874
Substrate
n/a
Meas. Tech.
ChEMBL_1878644 (CHEMBL4380038)
IC50
292±n/a nM
Citation
 Hlavá?, M; Ková?iková, L; Prnová, M?; ?ramel, P; Addová, G; Májeková, M; Hanquet, G; Bohá?, A; ?tefek, M Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem 63:369-381 (2020) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50519874
Synonyms:
CHEMBL4582264
Type:
Small organic molecule
Emp. Form.:
C11H8N4O3
Mol. Mass.:
244.2062
SMILES:
OC(=O)Cn1c2ccccc2c2n[nH]c(=O)nc12
Structure:
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