Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50074315
Substrate
n/a
Meas. Tech.
ChEMBL_46641 (CHEMBL658897)
Ki
346±n/a nM
Citation
 Lan, R; Liu, Q; Fan, P; Lin, S; Fernando, SR; McCallion, D; Pertwee, R; Makriyannis, A Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem 42:769-76 (1999) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50074315
Synonyms:
5-(2-Amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide | CHEMBL424527
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2N5O
Mol. Mass.:
444.357
SMILES:
Cc1c(nn(c1-c1ccccc1N)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |(2.9,-5.18,;3.85,-6.4,;5.39,-6.33,;5.92,-7.78,;4.7,-8.74,;3.41,-7.87,;1.97,-8.41,;1.73,-9.93,;.29,-10.44,;-.9,-9.47,;-.64,-7.94,;.8,-7.42,;.78,-5.88,;4.76,-10.28,;3.47,-11.08,;3.51,-12.62,;4.88,-13.35,;4.92,-14.89,;6.17,-12.53,;6.11,-10.99,;7.42,-10.17,;6.24,-5.05,;5.56,-3.67,;7.78,-5.17,;8.64,-3.88,;7.96,-2.51,;8.83,-1.23,;10.37,-1.33,;11.02,-2.73,;10.17,-3.99,)|
Structure:
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