Reaction Details Report a problem with these data
Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50520253
Substrate
n/a
Meas. Tech.
ChEMBL_1879553 (CHEMBL4380947)
IC50
89±n/a nM
Citation
 Kwiatkowski, J; Liu, B; Pang, S; Ahmad, NHB; Wang, G; Poulsen, A; Yang, H; Poh, YR; Tee, DHY; Ong, E; Retna, P; Dinie, N; Kwek, P; Wee, JLK; Manoharan, V; Low, CB; Seah, PG; Pendharkar, V; Sangthongpitag, K; Joy, J; Baburajendran, N; Jansson, AE; Nacro, K; Hill, J; Keller, TH; Hung, AW Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2. J Med Chem 63:621-637 (2020) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50520253
Synonyms:
CHEMBL4587832
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3
Mol. Mass.:
378.4244
SMILES:
CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1
Structure:
Search PDB for entries with ligand similarity: