Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM50520258
Substrate
n/a
Meas. Tech.
ChEMBL_1879552 (CHEMBL4380946)
IC50
820±n/a nM
Citation
 Kwiatkowski, JLiu, BPang, SAhmad, NHBWang, GPoulsen, AYang, HPoh, YRTee, DHYOng, ERetna, PDinie, NKwek, PWee, JLKManoharan, VLow, CBSeah, PGPendharkar, VSangthongpitag, KJoy, JBaburajendran, NJansson, AENacro, KHill, JKeller, THHung, AW Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2. J Med Chem 63:621-637 (2020) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM50520258
Synonyms:
CHEMBL4537933
Type:
Small organic molecule
Emp. Form.:
C14H15N3O2
Mol. Mass.:
257.2878
SMILES:
NCCOc1cc(ccc1C(N)=O)-c1cccnc1
Structure:
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