Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074527
Substrate
n/a
Meas. Tech.
ChEMBL_51114 (CHEMBL664960)
Ki
9.8±n/a nM
Citation
 Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem 42:833-48 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074527
Synonyms:
CHEMBL169641 | [3-(2-Bromo-4-isopropyl-phenyl)-2,5-dimethyl-3H-imidazo[4,5-b]pyridin-7-yl]-bis-(2-methoxy-ethyl)-amine
Type:
Small organic molecule
Emp. Form.:
C23H31BrN4O2
Mol. Mass.:
475.422
SMILES:
COCCN(CCOC)c1cc(C)nc2n(c(C)nc12)-c1ccc(cc1Br)C(C)C |(13.97,1.76,;13.97,.21,;12.64,-.56,;12.64,-2.11,;11.31,-2.87,;9.98,-2.11,;8.65,-2.87,;7.3,-2.11,;5.97,-2.87,;11.31,-4.41,;9.98,-5.18,;9.98,-6.72,;8.63,-7.5,;11.31,-7.49,;12.64,-6.72,;14.11,-7.19,;15.01,-5.95,;16.55,-5.97,;14.11,-4.71,;12.64,-5.18,;14.74,-8.6,;13.83,-9.84,;14.46,-11.26,;15.99,-11.42,;16.9,-10.17,;16.27,-8.76,;17.18,-7.51,;16.6,-12.84,;15.69,-14.08,;18.14,-13.01,)|
Structure:
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