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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074525
Substrate
n/a
Meas. Tech.
ChEMBL_51114 (CHEMBL664960)
Ki
4±n/a nM
Citation
 Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem 42:833-48 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074525
Synonyms:
CHEMBL355689 | [5-Methyl-3-(2,4,6-trimethyl-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-(1-propyl-butyl)-amine
Type:
Small organic molecule
Emp. Form.:
C21H30N6
Mol. Mass.:
366.5031
SMILES:
CCCC(CCC)Nc1nc(C)nc2n(nnc12)-c1c(C)cc(C)cc1C |(7.49,-7.24,;8.82,-6.47,;8.82,-4.93,;10.15,-4.16,;10.15,-2.61,;8.82,-1.84,;8.82,-.29,;11.49,-4.93,;11.49,-6.47,;10.15,-7.24,;10.15,-8.78,;8.8,-9.55,;11.49,-9.55,;12.82,-8.78,;14.28,-9.25,;15.17,-8,;14.28,-6.77,;12.82,-7.24,;14.61,-10.76,;16.06,-11.23,;17.2,-10.2,;16.39,-12.72,;15.26,-13.77,;15.59,-15.27,;13.79,-13.28,;13.46,-11.79,;11.99,-11.32,)|
Structure:
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