Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1
Ligand
BDBM50106393
Substrate
n/a
Meas. Tech.
ChEMBL_1879631 (CHEMBL4381025)
Ki
302000±n/a nM
Citation
 Solbak, SMØ; Zang, J; Narayanan, D; Høj, LJ; Bucciarelli, S; Softley, C; Meier, S; Langkilde, AE; Gotfredsen, CH; Sattler, M; Bach, A Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. J Med Chem 63:1156-1177 (2020) [PubMed]  Article 
Target
Name:
Neutrophil cytosol factor 1
Synonyms:
47 kDa autosomal chronic granulomatous disease protein | 47 kDa neutrophil oxidase factor | NCF-1 | NCF-47K | NCF1 | NCF1_HUMAN | NOXO2 | Neutrophil NADPH oxidase factor 1 | Neutrophil cytosol factor 1 | Nox organizer 2 | Nox-organizing protein 2 | SH3 and PX domain-containing protein 1A | SH3PXD1A | p47-phox
Type:
PROTEIN
Mol. Mass.:
44694.41
Organism:
Homo sapiens
Description:
ChEMBL_103757
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM50106393
Synonyms:
1-(pyridin-4-yl)piperazine | 1-Pyridin-4-yl-piperazine | CHEMBL339069
Type:
Small organic molecule
Emp. Form.:
C9H13N3
Mol. Mass.:
163.2196
SMILES:
C1CN(CCN1)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: