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Target
Neutrophil elastase
Ligand
BDBM50520503
Substrate
n/a
Meas. Tech.
ChEMBL_1880499 (CHEMBL4381893)
IC50
5850±n/a nM
Citation
 Scheeff, S; Rivière, S; Ruiz, J; Abdelrahman, A; Schulz-Fincke, AC; Köse, M; Tiburcy, F; Wieczorek, H; Gütschow, M; Müller, CE; Menche, D Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. J Med Chem 63:1684-1698 (2020) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50520503
Synonyms:
CHEMBL4471610
Type:
Small organic molecule
Emp. Form.:
C30H44O5
Mol. Mass.:
484.6674
SMILES:
CO[C@H]1[C@@H](C)[C@H](O)\C=C\C(\C)=C/C(/C)=C\[C@H](C)[C@H](O)\C=C(/C)\C=C\CC(=O)OCC\C=C\C=C1/C |r,c:10,13,19,t:7,22,30,32|
Structure:
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