Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50074979
Substrate
n/a
Meas. Tech.
ChEMBL_70880 (CHEMBL684538)
EC50
660±n/a nM
Citation
 Heitsch, H; Wagner, A; Schölkens, BA; Wirth, K Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors. Bioorg Med Chem Lett 9:327-32 (1999) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor
Type:
n/a
Mol. Mass.:
42217.03
Organism:
Cavia porcellus
Description:
n/a
Residue:
372
Sequence:
MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
  
Inhibitor
Name:
BDBM50074979
Synonyms:
(E)-3-(4-Methoxy-phenyl)-N-({methyl-[3-(2-methyl-quinolin-8-yloxymethyl)-2,4-bis-methylsulfanyl-phenyl]-carbamoyl}-methyl)-acrylamide | CHEMBL114915
Type:
Small organic molecule
Emp. Form.:
C32H33N3O4S2
Mol. Mass.:
587.752
SMILES:
COc1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1
Structure:
Search PDB for entries with ligand similarity: