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Target
Carbonic anhydrase 2
Ligand
BDBM50520683
Substrate
n/a
Meas. Tech.
ChEMBL_1881816 (CHEMBL4383315)
IC50
29±n/a nM
Citation
 Ameryckx, A; Thabault, L; Pochet, L; Leimanis, S; Poupaert, JH; Wouters, J; Joris, B; Van Bambeke, F; Frédérick, R 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. Eur J Med Chem 159:324-338 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50520683
Synonyms:
CHEMBL4476621
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2N3O2S
Mol. Mass.:
356.227
SMILES:
Oc1ccccc1C(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1
Structure:
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