Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50075346
Substrate
n/a
Meas. Tech.
ChEBML_195319
Kd
60±n/a nM
Citation
 Johnson, AT; Wang, L; Gillett, SJ; Chandraratna, RA High affinity retinoic acid receptor antagonists: analogs of AGN 193109. Bioorg Med Chem Lett 9:573-6 (1999) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50075346
Synonyms:
4-[8-(4-Methoxy-phenyl)-5,5-dimethyl-5,6-dihydro-naphthalen-2-ylethynyl]-benzoic acid | CHEMBL346202
Type:
Small organic molecule
Emp. Form.:
C28H24O3
Mol. Mass.:
408.4884
SMILES:
COc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O |t:9|
Structure:
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