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Target
Serine protease 1
Ligand
BDBM50063745
Substrate
n/a
Meas. Tech.
ChEBML_212340
IC50
>100000±n/a nM
Citation
 Plummer, JS; Cai, C; Hays, SJ; Gilmore, JL; Emmerling, MR; Michael, W; Narasimhan, LS; Watson, MD; Wang, K; Nath, R; Evans, LM; Jaen, JC Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease. Bioorg Med Chem Lett 9:815-20 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50063745
Synonyms:
2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][1,3]oxazin-4-one | CHEMBL10312
Type:
Small organic molecule
Emp. Form.:
C15H8F3IN2O2
Mol. Mass.:
432.1359
SMILES:
FC(F)(F)c1ccc2c(c1)nc(Nc1ccccc1I)oc2=O
Structure:
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