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Target
Stimulator of interferon genes protein
Ligand
BDBM50521331
Substrate
n/a
Meas. Tech.
ChEMBL_1884007 (CHEMBL4385506)
IC50
11000±n/a nM
Citation
 Siu, T; Altman, MD; Baltus, GA; Childers, M; Ellis, JM; Gunaydin, H; Hatch, H; Ho, T; Jewell, J; Lacey, BM; Lesburg, CA; Pan, BS; Sauvagnat, B; Schroeder, GK; Xu, S Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING. ACS Med Chem Lett 10:92-97 (2019) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50521331
Synonyms:
CHEMBL4557373 | US11311528, Ex. 1-85
Type:
Small organic molecule
Emp. Form.:
C29H27ClFNO5
Mol. Mass.:
523.98
SMILES:
CC(C)(C)c1ccc(cc1Cl)N1[C@@H]([C@@H](CC(O)=O)c2ccc(F)cc2C1=O)c1ccc2OCCOc2c1 |r|
Structure:
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