Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM429036
Substrate
n/a
Meas. Tech.
ChEMBL_1884336 (CHEMBL4385918)
Ki
22±n/a nM
Citation
Lee, T; Christov, PP; Shaw, S; Tarr, JC; Zhao, B; Veerasamy, N; Jeon, KO; Mills, JJ; Bian, Z; Sensintaffar, JL; Arnold, AL; Fogarty, SA; Perry, E; Ramsey, HE; Cook, RS; Hollingshead, M; Davis Millin, M; Lee, KM; Koss, B; Budhraja, A; Opferman, JT; Kim, K; Arteaga, CL; Moore, WJ; Olejniczak, ET; Savona, MR; Fesik, SW Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem 62:3971-3988 (2019) [PubMed] Article
More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM429036
Synonyms:
US10533010, Example I-133 | US11208415, Example I-133
Type:
Small organic molecule
Emp. Form.:
C38H40Cl2N4O4
Mol. Mass.:
687.655
SMILES:
CC1CN(Cc2ccc(cc2)C(O)=O)C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n2C1 |(-.84,7.04,;-.84,5.5,;.52,4.77,;.8,3.25,;2.28,2.85,;3.37,3.94,;4.86,3.54,;5.95,4.63,;5.59,6.16,;4.06,6.52,;2.97,5.43,;6.68,7.25,;6.28,8.74,;8.17,6.85,;-.22,2.09,;.55,.76,;-1.76,2.09,;-2.66,.85,;-2.26,-.64,;-.77,-1.04,;-.38,-2.53,;1.11,-2.93,;1.51,-4.41,;3,-4.81,;3.4,-6.3,;4.88,-6.7,;2.31,-7.39,;2.71,-8.88,;.82,-6.99,;-.27,-8.08,;.42,-5.5,;-4.13,1.32,;-5.46,.55,;-6.79,1.32,;-6.79,2.86,;-8.13,3.63,;-5.46,3.63,;-5.46,5.17,;-4.21,6.08,;-2.88,5.31,;-4.69,7.54,;-6.23,7.54,;-7,8.88,;-6.71,6.08,;-8.04,5.31,;-4.13,2.86,;-2.66,3.34,;-2.25,4.89,)|