Reaction Details Report a problem with these data
Target
Arginase
Ligand
BDBM50521944
Substrate
n/a
Meas. Tech.
ChEMBL_1885817 (CHEMBL4387399)
IC50
12000±n/a nM
Citation
 Crizanto de Lima, E; Castelo-Branco, FS; Maquiaveli, CC; Farias, AB; Rennó, MN; Boechat, N; Silva, ER Phenylhydrazides as inhibitors of Leishmania amazonensis arginase and antileishmanial activity. Bioorg Med Chem 27:3853-3859 (2019) [PubMed]  Article 
Target
Name:
Arginase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
36149.67
Organism:
Leishmania amazonensis
Description:
ChEMBL_107995
Residue:
329
Sequence:
MEHVQQYKFYKEKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISDGRAIARCMMGETLLYTPHTSSKL
  
Inhibitor
Name:
BDBM50521944
Synonyms:
CHEMBL4204512
Type:
Small organic molecule
Emp. Form.:
C17H17F2N3O2
Mol. Mass.:
333.3326
SMILES:
CC(=O)Nc1ccc(C)cc1C(F)(F)C(=O)NNc1ccccc1
Structure:
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