Reaction Details Report a problem with these data
Target
Pyrroline-5-carboxylate reductase 1, mitochondrial
Ligand
BDBM50522088
Substrate
n/a
Meas. Tech.
ChEMBL_1885981 (CHEMBL4387563)
IC50
8800±n/a nM
Citation
 Milne, K; Sun, J; Zaal, EA; Mowat, J; Celie, PHN; Fish, A; Berkers, CR; Forlani, G; Loayza-Puch, F; Jamieson, C; Agami, R A fragment-like approach to PYCR1 inhibition. Bioorg Med Chem Lett 29:2626-2631 (2019) [PubMed]  Article 
Target
Name:
Pyrroline-5-carboxylate reductase 1, mitochondrial
Synonyms:
1.5.1.2 | P5C reductase 1 | P5CR 1 | P5CR1_HUMAN | PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial
Type:
PROTEIN
Mol. Mass.:
33365.79
Organism:
Homo sapiens
Description:
ChEMBL_118247
Residue:
319
Sequence:
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
  
Inhibitor
Name:
BDBM50522088
Synonyms:
CHEMBL4442920
Type:
Small organic molecule
Emp. Form.:
C11H12BrN
Mol. Mass.:
238.124
SMILES:
CN(CC#C)Cc1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: