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Target
Endoplasmic reticulum chaperone BiP
Ligand
BDBM31712
Substrate
n/a
Meas. Tech.
ChEMBL_1887314 (CHEMBL4388991)
IC50
9100±n/a nM
Citation
 Ambrose, AJ; Zerio, CJ; Sivinski, J; Schmidlin, CJ; Shi, T; Ross, AB; Widrick, KJ; Johnson, SM; Zhang, DD; Chapman, E A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorg Med Chem Lett 29:1689-1693 (2019) [PubMed]  Article 
Target
Name:
Endoplasmic reticulum chaperone BiP
Synonyms:
Heat shock protein family A member 5 | HSPA5 | HSP70 family protein 5 | BiP | GRP78 | 3.6.4.10 | 78 kDa glucose-regulated protein | Synonyms=GRP78 | Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 | BIP_HUMAN | Heat shock 70 kDa protein 5 | Immunoglobulin heavy chain-binding protein | Heat shock protein 70 family protein 5 | Binding-immunoglobulin protein | GRP-78
Type:
n/a
Mol. Mass.:
72312.92
Organism:
Human
Description:
P11021
Residue:
654
Sequence:
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
  
Inhibitor
Name:
BDBM31712
Synonyms:
SMR000058356 | MLS000028433 | cid_3598 | HEXACHLOROPHENE | Hexach-lorophene
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: