Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50523423
Substrate
n/a
Meas. Tech.
ChEMBL_1890310 (CHEMBL4392064)
Ki
158±n/a nM
Citation
 Yang, X; van Veldhoven, JPD; Offringa, J; Kuiper, BJ; Lenselink, EB; Heitman, LH; van der Es, D; IJzerman, AP Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A J Med Chem 62:3539-3552 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50523423
Synonyms:
CHEMBL4548863
Type:
Small organic molecule
Emp. Form.:
C24H26FN5O6S
Mol. Mass.:
531.557
SMILES:
CCCn1c(=O)n(CCCCNC(=O)c2cccc(c2)S(F)(=O)=O)c2nc3cc(OC)ccn3c2c1=O
Structure:
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