Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50523424
Substrate
n/a
Meas. Tech.
ChEMBL_1890313 (CHEMBL4392067)
Ki
1259±n/a nM
Citation
 Yang, X; van Veldhoven, JPD; Offringa, J; Kuiper, BJ; Lenselink, EB; Heitman, LH; van der Es, D; IJzerman, AP Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A J Med Chem 62:3539-3552 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50523424
Synonyms:
CHEMBL4439336
Type:
Small organic molecule
Emp. Form.:
C23H24FN5O6S
Mol. Mass.:
517.53
SMILES:
CCCn1c(=O)n(CCCNC(=O)c2ccc(cc2)S(F)(=O)=O)c2nc3cc(OC)ccn3c2c1=O
Structure:
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