Reaction Details Report a problem with these data
Target
N-terminal Xaa-Pro-Lys N-methyltransferase 1
Ligand
BDBM50523489
Substrate
n/a
Meas. Tech.
ChEMBL_1890449 (CHEMBL4392203)
Ki
39±n/a nM
Citation
 Chen, D; Dong, G; Noinaj, N; Huang, R Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1. J Med Chem 62:3773-3779 (2019) [PubMed]  Article 
Target
Name:
N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms:
2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A
Type:
PROTEIN
Mol. Mass.:
25382.72
Organism:
Homo sapiens
Description:
ChEMBL_119192
Residue:
223
Sequence:
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
  
Inhibitor
Name:
BDBM50523489
Synonyms:
CHEMBL4518093
Type:
Small organic molecule
Emp. Form.:
C48H82N18O11
Mol. Mass.:
1087.2787
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1CCCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)N[C@@H](C)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: