Reaction Details Report a problem with these data
Target
Thiosulfate sulfurtransferase
Ligand
BDBM24778
Substrate
n/a
Meas. Tech.
ChEMBL_1891102 (CHEMBL4392929)
IC50
1000±n/a nM
Citation
 Stevens, M; Abdeen, S; Salim, N; Ray, AM; Washburn, A; Chitre, S; Sivinski, J; Park, Y; Hoang, QQ; Chapman, E; Johnson, SM HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett 29:1106-1112 (2019) [PubMed]  Article 
Target
Name:
Thiosulfate sulfurtransferase
Synonyms:
2.8.1.1 | Rhodanese | Thiosulfate sulfurtransferase | THTR_HUMAN | TST
Type:
PROTEIN
Mol. Mass.:
33432.06
Organism:
Human
Description:
ChEMBL_118080
Residue:
297
Sequence:
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
  
Inhibitor
Name:
BDBM24778
Synonyms:
Vitamin K3 | cid_4055 | 2-methyl-1,4-dihydronaphthalene-1,4-dione | Menadione (Vitamin K3) | CHEMBL590 | Menadione | Menadione, 9 | 2-methyl-1,4-naphthoquinone, 5 | Menadione (5d)
Type:
Small organic molecule
Emp. Form.:
C11H8O2
Mol. Mass.:
172.05
SMILES:
CC1=CC(=O)c2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: