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Target
Kv channel-interacting protein 2
Ligand
BDBM50524103
Substrate
n/a
Meas. Tech.
ChEMBL_1891917 (CHEMBL4393838)
IC50
>33000±n/a nM
Citation
 Pettersen, D; Broddefalk, J; Emtenäs, H; Hayes, MA; Lemurell, M; Swanson, M; Ulander, J; Whatling, C; Amilon, C; Ericsson, H; Westin Eriksson, A; Granberg, K; Plowright, AT; Shamovsky, I; Dellsèn, A; Sundqvist, M; Någård, M; Lindstedt, EL Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem 62:4312-4324 (2019) [PubMed]  Article 
Target
Name:
Kv channel-interacting protein 2
Synonyms:
A-type potassium channel modulatory protein 2 | Cardiac voltage-gated potassium channel modulatory subunit | KCHIP2 | KCIP2_HUMAN | KCNIP2 | Kv channel-interacting protein 2 | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium channel-interacting protein 2
Type:
PROTEIN
Mol. Mass.:
30896.89
Organism:
Homo sapiens
Description:
ChEMBL_117142
Residue:
270
Sequence:
MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQALPSVSETLAAPASLRPHRPRLLDPDSVDDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTVDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDNVI
  
Inhibitor
Name:
BDBM50524103
Synonyms:
CHEMBL4563459
Type:
Small organic molecule
Emp. Form.:
C27H34N6O4
Mol. Mass.:
506.5967
SMILES:
Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1C(=O)NOC(C)(C)C |r|
Structure:
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